HighlightsThe potential systemic toxicity and mutagenicity of Oligopin®, a French Maritime Pine Bark extract, was evaluated.Oligopin® was nongenotoxic in both bacterial and human cell assays.Oligopin® was not acutely toxic and 90 days of oral administration to rats was well tolerated with a NOAEL of 1000 mg/kg/day.The lack of adverse systemic effects in the 90 day study is concordant with findings from human clinical trials.The NOAEL from the 90-day study suggests that Oligopin® is less systemically toxic than other FMPBE evaluated in subchronic studies.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.