The purpose of this qualitative descriptive study was to explore the phenomenon of women's experience with infertility in the aftermath of unsuccessful medical treatment. A purposive sample of 22 women between the ages of 33 and 48 years participated in a hermeneutic-phenomenological research process and were interviewed an average of 3.9 years after unsuccessful medical treatment. Women described the existential challenges to their sense of self, their identity, and the meaning and purpose of life. The paradoxical dimensions of loss and opportunity in their experience contributed to an altered view of themselves and their world. Infertility and its role as a life-defining experience pervaded their stories of living with infertility after unsuccessful treatment. Health care professionals are advised to assess women's overall well-being, mental health status with particular attention to spiritual well-being, and their social support network as a basis for determining supportive services that may be required in the wake of unsuccessful treatment for infertility.

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Despite the elevated crude recorded prevalence of HIV, multivariate analyses suggested that HIV-related risk factors underlie the associations between HIV and the serious mental illness diagnoses. For patients with schizophrenia, this study is the first to demonstrate reduced HIV risk in the absence of a substance use disorder.

The authors propose that the evolution of the role development for generalist and advanced practice nursing is increasingly at odds with the contemporary scholarship of the discipline and ultimately betrays the unique identity and autonomy of the nursing profession. The development of the evidence-based practice movement in medicine and nursing is explored as the predominant theoretical framework guiding nursing practice. Professional challenges and recommendations to reclaim the unique nature of nursing are discussed with attention to the implications for the educator, clinician, and scholar.

Women who did not seek treatment for perceived infertility problems reported a decreased sense of the importance of parenthood but also reported lower levels of self-esteem and life satisfaction than women who sought treatment, regardless of treatment outcome.