Findings suggest that milk intake is associated with an increased risk of Parkinson disease. Whether observed effects are mediated through nutrients other than calcium or through neurotoxic contaminants warrants further study.
ObjectivesIn light of the need to develop an integrated database on poisoning incidents in Korea, this study seeks to determine the characteristics of poisoning incidents in Korea by age, gender, location of incident, causative substance and patient prognosis.Data sourcesThe Korea National Hospital Discharge In-Depth Injury Survey results (2005–2009) from the Korea Centers for Disease Control and Prevention were used.Participants3826 participants in the survey who had been hospitalised for poisoning incidents.ResultsThe poisoning hospitalisation rate per 100 000 population was higher in women (1.735) than in men (1.372) and increased with age: the rate was 0.458 among individuals aged ≤9 years, 0.481 among those aged 10–19 years, 1.584 among those aged 20–64 years and 4.053 among those aged ≥65 years. The intentional poisoning hospitalisation rate differed by gender and age group. Women aged ≤19 years and 20–64 years showed a higher hospitalisation rate than men, while men aged ≥65 years showed a higher hospitalisation rate than women in the same age group. The most common poisoning substance was pesticides (33.6%), while antiepileptic, sedative-hypnotic and antiparkinsonism drugs and psychotropic drugs, not elsewhere classified were also very common. Poisoning in those aged ≤9 years usually involved other drugs, while pesticides were the most common substances in those aged 20–64 years and ≥65 years.ConclusionsThis study analysed poisoning incidents in Korea from 2005 to 2009, by age and gender, causative substance, and characteristics. The results of this study may serve as evidence for new strategies in Korea to prevent poisoning.
SUMMARY In this study, a series of computational fluid dynamics (CFD) numerical analyses was performed in order to evaluate the performance of six full‐scale closed‐loop vertical ground heat exchangers constructed in a test bed located in Wonju, South Korea. The high‐density polyethylene pipe, borehole grouting and surrounding ground formation were modeled using FLUENT, a finite‐volume method program, for analyzing the heat transfer process of the system. Two user‐defined functions accounting for the difference in the temperatures of the circulating inflow and outflow fluid and the variation of the surrounding ground temperature with depth were adopted in the FLUENT model. The relevant thermal properties of materials measured in laboratory were used in the numerical analyses to compare the thermal efficiency of various types of the heat exchangers installed in the test bed. The numerical simulations provide verification for the in‐situ thermal response test (TRT) results. The numerical analysis with the ground thermal conductivity of 4.0 W/m⋅K yielded by the back‐analysis was in better agreement with the in‐situ TRT result than with the ground thermal conductivity of 3.0 W/m⋅K. From the results of CFD back‐analyses, the effective thermal conductivities estimated from both the in‐situ TRT and numerical analysis are smaller than the ground thermal conductivity (=4.0 W/m∙K) that is input in the numerical model because of the intrinsic limitation of the line source model that simplifies a borehole assemblage as an infinitely long line source in the homogeneous material. However, the discrepancy between the ground thermal conductivity and the effective thermal conductivity from the in‐situ TRT decreases when borehole resistance decreases with a new three pipe‐type heat exchanger leads to less thermal interference between the inlet and outlet pipes than the conventional U‐loop type heat exchanger. Copyright © 2012 John Wiley & Sons, Ltd.
SUMMARYIn spinal cord injury (SCI), the scar-forming reactive astrocytes with upregulated GFAP proliferate aberrantly near the injury site, allowing themselves as a prime target for transdifferentiation into neurons to replenish dead neurons. However, the conventional use of GFAP promoter to target reactive astrocytes has two inherent problems: inadvertent conversion of normal astrocytes and low efficiency due to progressive weakening of promoter activity during transdifferentiation. Here, we report that the scar-forming reactive astrocytes are selectively transdifferentiated into neurons with 87% efficiency and 96% specificity via TRANsCre-DIONE, a combination of the split-Cre system under two different promoters of GFAP and Lcn2 and a Cre-loxP-dependent inversion and expression of Neurog2 under the strong EF1α promoter. After SCI, TRANsCre-DIONE caused transdifferentiation into Isl1-positive motor neurons, reduced astrogliosis, enhanced regeneration in surrounding cells, and a significant motor recovery. Our study proposes TRANsCre-DIONE as the next-generation therapeutic approach for patients suffering from SCI.HighlightsTRANsCre-DIONE converts reactive astrocyte into neuron by over-expression of Neurog2 Reactive astrocytes are targeted using split-Cre under two promoters, GFAP and Lcn2 TRANsCre-DIONE reduces reactivity, replaces dead neurons and alleviates symptom of SCI Transdifferentiated-neurons are GABA+ in the striatum and Isl1+ in the spinal cord
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