In patients serologically positive for Trypanosoma cruzi infection the three bug species/instar combinations used in xenodiagnosis showed third-instar Dipetalogaster maximus to be more efficient in detecting circulating trypanosomes than the first instar of the same species which, in turn, is more sensitive than third-instar Triatoma infestans. The sensitivity of the pool technique of faecal examination compared with individual dissection was investigated. Four pool examinations (the product of 20 bugs) were equivalent to 10 individual bug dissections. Because of the ease of providing large numbers of bugs for mass xenodiagnosis, first-instar D. maximus has replaced third-instar T. infestans in our routine work. The value of third-instar D. maximus as a xenodiagnostic agent needs further investigation.
Two stocks of Trypanosoma cruzi isolated from patients with advanced megaoesophagus produced megastomach in chronically infected mice. The mice showed evidence of stomach dilatation and a delay in intestinal transit time. These findings are discussed in the light of the hypothesis that regional variations in T. cruzi determines mega formation in man.
Recentemente demonstrou-se que cepas de Trypanosoma cruzi, isoladas de pacientes apre sentando megaesôfago, puderam produzir megaestômago em camundongos após cerca de 1 ano de infecção1. Megaestômago pode ser detectado em animais vivos por contraste de bário, sendo que não se detectou ocorrência de megaesôfago ou megacólon nos animais infectados, nem mesmo pela autópsia, embora estes animais apresentassem uma sensível demora de tem po no trânsito intestinal, quando comparados com animais normais.No sentido de estender essas observações, in vestigou-se a capacidade de produção de "Megas" a partir de cepas de diferentes origens, bem como seu com portam ento em comparação com uma das cepas utilizadas no trabalho citado acima.Foram feitas observações sobre a acuidade do m étodo de medida do perfil radiográfico do es tômago como medida alternativa e válida do volu me deste mesmo órgão.
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