This paper concerns the analysis of adventitious sounds produced by individual asthmatic patients, and relates the sounds to the degree of airways obstruction at the moment of sound recording. In this study, airways obstruction is represented by a parameter commonly used in clinical tests, the forced expiratory volume in one second. A nonrestrictive approach using spectral information in detail is followed, resulting in a fairly high resolution of respiration sounds with respect to airways obstruction. The beneficial effect of a power raising transformation is presented, together with an illumination of the background of this effect.
The characteristics and diagnostics of wheezing during induced airway obstruction are well documented. The present study addressed (a) the characteristics of spontaneous wheezing with respect to a possible distinction between wheezes during in vivo versus induced airway obstruction, and (b) the relationship between in vivo wheezing and fluctuations in peak expiratory flow (PEF). Tracheal sounds were continuously recorded from 50 children and adolescents with asthma and 10 without asthma in the home environment. Wheezes underwent a qualitative analysis, including their concomitant sound frequencies. Presence of wheezing was scored by two examiners independently and was related to PEF. Spontaneous wheeze varied from solitary rhonchi to prolonged rhythms of loud stridor, and resembled the "induced" wheezes recorded previously. Power spectra showed that the spectral contents (frequency distribution) were comparable, although the in vivo patterns were more prolonged in duration. The diagnostic sensitivity and specificity of wheezing for a reduction in PEF of >20% were 88% and 92%, respectively. It was concluded that in vivo wheeze resembled induced wheeze and was a diagnostically reliable symptom with respect to asthma exacerbations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.