The experimentally determined kinematic viscosities of simple triacylglycerols [trilaurin, trimyristin (MMM), tripalmitin (PPP), tristearin (SSS), triolein (OOO), and trilinolein (LiLiLi) were correlated to a modified Andrade-type equation. The constants for the modified equation were derived for each simple triacylglycerol. The method was also used to estimate the viscosity of mixed triacylglycerols [1,2-dimyristoyl-3-palmitoyl (MMP), 1,2-dioleoyl-3-palmitoyl (OOP), 1,2-dimyristoyl-3-oleoyl (MMO), and 1,2-dipalmitoyl-3-oleoyl (PPO)], binary triacylglycerol mixtures (PPO/OOP, PPP/SSS, and OOO/SSS of different portions), and three types of vegetable oils [refined, bleached, and deodorized palm oil; cocoa butter; and canola oil] by applying modified Kay's rule utilizing the simple triacylglycerol constants derived earlier. In all cases, the estimated values for liquid viscosity were compared with experimental values determined in this work and with previous work from the literature. When applied to vegetable oils, the method requires knowledge of their triacylglycerol composition. Despite its simplicity, the method gives a reasonable estimate. The method may be used to predict the viscosity of different blends of vegetable oils, and the accuracy is expected to increase when more experimental data on simple triacylglycerols become available.
The liver cells were cultured in the presence of ginger extract at various concentrations (0-1 mg /ml) for 24 h and the cells viability and proliferation rate were evaluated by MTS and BrdU assays, while apoptosis was evaluated by colorimetric determination of caspase 8 and 3 activities. Ginger extract exhibited a dose dependent inhibition of viability and proliferation of WRL-68, HLE and HepG2 cells with IC50 of 569.69 ± 7.99 µg/ml, 389.71 ± 26.56 µg/ml and 358.71 ± 17.12 µg/ml respectively. Ginger extract induced apoptosis through activation of caspase-8 and 3 in a dose dependent pattern for all cells at concentration ranging from 0-500 g/ml. We found that antiproliferative effect of ginger extract could be associated with induction of apoptosis as shown by increased activities of caspase 8 and 3.The results from this study suggest that ginger extract has chemopreventive properties against hepatoma cells HepG2 and HLE by inhibiting cellular proliferation and inducing apoptosis.
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