Objective: To investigate the level and relationship of specific immunoglobulin G (IgG) antibodies to SARS-CoV-2 with laboratory parameters of vascular inflammatory response (VIR) during follow-up of patients with arterial hypertension (AH) in 3 months after disease onset. Design and method: Retrospective, single-center observational study included 76 confirmed cases of COVID-19 associated with pneumonia (April-May 2020). Gr.1 consisted of 32 patients without AH; Gr.2 involved 44 AH patients, including 18 patients with metabolic disorders (abdominal obesity and impaired carbohydrate metabolism). Complete blood count, biochemical and hemostatic parameters were determined on the day of admission. Comprehensive analysis of clinical instrumental and laboratory parameters, including blood pressure, heart rate, IgG (positivity rate), cytokines, NT-pro BNP, endothelial dysfunction markers, cystatin C, glucose and others was performed in 3 months after discharge. Results: In Gr.1, IgG was negatively associated with hemoglobin, red blood cell volume, neutrophils, creatine phosphokinase, homocysteine, those were supplemented by NT-pro BNP, interleukin-6, lactate dehydrogenase, creatinine (p < 0.0001–0.034) in Gr.2 and additionally, D-dimer level, transforming growth factor and P-selectin (p < 0.001–0.036) in metabolic disorders subgroup. Therewith, in patients aged over 40 years, positive association of IgG with levels of SBP and DBP (p < 0.011 and 0.034), MDRD (p < 0.01) was registered. Correlation and regression analysis revealed greater association of IgG level < 12.9 with vascular inflammatory markers, and IgG level > 12.9 with thrombogenic parameters. Conclusions: IgG might be a sensitive indicator of VIR and can play a role in predicting possible unwanted vascular complications in AH patients after suffering from SARS-CoV-2.
Background: Hypertension is a problem that needs to be watched out for because there are no specific signs and symptoms, of hypertension and some people still feel healthy to do their activities as usual, this is what makes hypertension a silent killer. Purpose: To determine the effect of chayote soup and celery leaves on blood pressure levels in respondents with hypertension in the East Kalabahi Village, Teluk Mutiara District, Alor Regency, NTT. Methods: This research is a quantitative study by conducting experiments to find the effect of treatment. The type of research used was pre-experimental designs (non-designs), with a one-group pre-test and post-test design. The sample used in this study was total sampling i.e. 30 people. Results: The results of the t-paired sample test for systolic blood pressure obtained t (29) = 9.798 p-value = 0.000 < α = 0.05 and the Wilcoxon Signed Ranks test for diastolic blood pressure yielded Z-count = -3.694 p-value = 0.000 < α = 0.05, which means H0 is rejected and Ha is accepted. Conclusion: There is an effect of giving chayote soup and celery leaves on blood pressure levels in hypertension sufferers in the Kalabahi Timur Village, Teluk Mutiara District, Alor Regency, NTT.
ObjectivesWe had to study local and systemic inflammation in rheumatoid arthritis patients with persistence Chlamydia trachomatis (Ch tr) in the jointMethods31 patients with early RA; mean age 54,5 (10,6) years, disease duration 21,5 (14,4) weeks witch persistence Ch tr in the joint (mRNP Ch tr had been revealed in synovial fluid by NASBA PCR) were enrolled in this study. The comarison group was patients with RA (n=42) without mRNP in synovial fluid (Ch tr-). Mean age was 51,7 (15,4) years, disease duration 20,8 (13,3) weeks. All the patients had been received only symptomatic treatment (NSAID). Disease activity had been detected by DAS 28. Systemic inflammation was estimated by levels of erythrocyte sedimentation rate (ESR), hsp C-reactive protein (hspCRP), orozomucoid (OR) in the blood samples; local inflammation- by detection hsp CRP, OR in synovial fluid. Also we had been detected level of ACCP in the blood samples and synovial fluid.ResultsWe didn't reveal statistically significant differences between levels of ESR, hsp CPR, OR, ACCP in blood samples patients with RA Chtr+ and RA Ch tr-. Level of hsp CPR and OR in synovial fluid of research group (Ch tr+) were significantly higher than comparison group (4,1±0,3 mg/l versus 2,4±0,2 mg/l, p<0,05 –hspCRP and 157,4±17,5mg/dl versus 78,5±18,9 mg/dl, p<0,001- OR). In the group of research (Ch tr+) level of ACCP in synovial fluid was statistically significant higher than comparison group (Ch.tr -) (195,6±37,3 versus 67,9±15,4; p<0,001)ConclusionsPatients with early RA detected by NASBA PCR in synovial fluid Ch tr+, had been characterized by absence differences compared RA Ch tr- patients in the level of systemic inflammation and had differences in the level of local inflammation. We revealed high level of ACCP in RA patients with Ch tr in the joints, that may be important for understanding some aspects of RA pathogenesis.Disclosure of InterestNone declared
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