Heparin does not increase blood loss or the need for blood transfusion during surgery. Heparin is not necessary to prevent distal thrombosis when the aorta is cross clamped. The results of the study are consistent with the known mechanisms leading to intraoperative MI and strategies for its prevention. Intravenous heparin, given before aortic cross clamping, is an important prophylaxic against perioperative MI in relation to AAA surgery.
We intend to develop a simple, reproducible, clinical model to test the null hypothesis thatthe effects of ultramolecular homoeopathic preparations are always equivalent to placebo. A pilot of a randomized, double-blind, placebo-controlled study was conducted to assess the effects of Arnica and Rhus tox 30c on delayed onset muscle soreness. 50 healthy volunteers undertook a standard bench-stepping exercise, with outcome assessed using a validated soreness scale. Though the results of the trial favoured homoeopathy, differences between groups were small and did not reach statistical signficance (p>0.2). A sub-group analysis of subjects who did not take vigorous exercise and who would therefore be expected to be more responsive to treatment showed clinically but not statistically significant differences between groups (p>0.2). A second trial is currently under way in an attempt to replicate these findings.
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