The data show letrozole 2.5 mg once daily to be more effective and better tolerated than MA in the treatment of postmenopausal women with advanced breast cancer previously treated with antiestrogens.

Given a favorable tolerability profile, once-daily dosing, and evidence of clinically relevant benefit, letrozole is equivalent to megestrol acetate and should be considered for use as an alternative treatment of advanced breast cancer in postmenopausal women after treatment failure with antiestrogens.

Improved diagnostic accuracy of a modified oral pancreatic function test. ScandJ3 Gastroenterol 1979 ;14 :737-41. 1 O'Donnel MD, Fitzgerald 0, McGeeney KF. Differential serum amylase determination by use of an inhibitor, and design of a routine procedure.

No abstract