Background: The liver is a vital organ in the human body involved in the metabolic processes. Any damage to the liver due to factors such as protein deficiency, viral infection, as well as consumption of alcohol, chemical contaminants, and adulterated foods. High blood cholesterol, high blood pressure, diabetes, lack of exercise, poor diet, obesity and cigarette smoking are major risk factor for stroke, heart attack and coronary heart disease (CHD). In medical science, number of synthetic drugs has discovered and used for treatment of people suffering from liver injury and CHD, but they were not always effective and sometimes difficult to manage by medical therapies and found also to be accompanied with other negative side effects. Objective: The review of the study was to critically review the recent research and studies of epidemiological and randomized control trials to find out the effective cereal protein as an alternative preventive food to reduce the CHD and protect the liver from viral hepatic diseases focusing daily food intake, body weight, liver weight, serum enzyme activities and cholesterols. Methods: A few of data was used from our experiment, a literature search was performed from reliable source of the published research article and reviewed papers, epidemiological and randomized control trials on the effects of cereal protein on animals and human intervention by Google, Google scholar, Redcube, Endnote, in Scopus, SpringerDirect.com, PubMed and Web of Science. Then the data was organized, summarized and analyzed. Results: In medical science, serum enzyme activities aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and lipid peroxidation stress malondialdehyde (MDA) are commonly used as biochemical markers of the liver damaging agent. Blood cholesterols (total cholesterol-TC, triglyceride-TG, low density lipoprotein cholesterol-LDLC and high-density lipoprotein cholesterol-HDLC) are used as the marker of heart diseases. The review shows that daily food intake and body weight data is not significantly differed among normal diet, casein (CAS) and cereals protein. The millet and wheat protein increases the liver weight whereas the rice protein lowers the liver weight. The intake of cereals protein significantly reduces the activities of serum AST, ALT, LDH, MDA, TC, TG and LDLC where it increases the HDLC. Conclusion: Experimental, review and randomized controls (RCTs) data confirm that cereal protein appears to be beneficial in reducing the hepatic liver injury and CHD by maintaining body weight, liver weight, blood pressure, serum enzyme activities AST, ALT and LDH, lipid peroxidation stress MDA and cholesterol concentrations both in plasma and liver.
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