Objective: Stem cells have remarkable potential to grow in more than 200 types of cells that the adult human body holds. Regenerative medicine by using stem cells is at the vanguard of health care poised to offer solutions for many of today's incurable diseases. Bone marrow derived stem cells have been used in vitro to generate bone, cartilage, tendon, ligament, meniscus, intervertebral disc, fat, muscle, and nerve. The aim of this review is to describe the stem cell therapy in Tajikistan and its position in the word. In Tajikistan for the first time the laboratory for investigation of stem cell created in Avicenna Tajik State Medical University, Dushanbe at November 29, 2009 and the first clinical study for heart stem cell therapy started at March 9, 2010. In this study, autologous transplantation of bone marrow derived CD133+ was undertaken with the high degree of success for a cohort of patients with coronary artery disease. Keywords: Regenerative medicine, human stem cells, cardiac revitalization, coronary artery disease, bone marrow derived CD133+.