Objective: Serrated colorectal lesions are a group of colonic lesions with a serrated (saw-tooth) profile of the surface epithelium and crypts and peculiar molecular and genetic developmental mechanisms that are incompletely understood. These formations cause concern due to their premalignant potential. Aim: The review is dedicated to serrated lesions of the colon and appendix. We focused on modern classification, its role in carcinogenesis, and new approaches to morphological diagnosis. Methods: A literature search was performed using PubMed, Scopus, ResearchGate, Google, MEDLINE, and ScienceDirect databases to find studies of serrated colorectal lesions related cancer published between 2000 and 2020 that address epidemiological of risk factors, underlying pathophysiological mechanism and enable our review of these factors as well molecular, genetics, and structural patterns. Results: Serrated colorectal lesions take one-third of all benign neoplasms of the colon in the pathologist’s practice. The active study of serrated lesions began in the 1900s. Terminology and diagnostic criteria were changed in the updated classification in 2019. Morphological criteria, immunohistochemical and molecular profile, endoscopic and clinical characteristics are reviewed. Conclusion: Significant efforts were made to improve our understanding and diagnostic criteria of serrated polyps of the colorectum. Very little change has occurred since the original morphologic description of preneoplastic serrated lesions in the early 2000s. More research remains needed to develop more definitive immunophenotypic and molecular biomarkers to distinguish between non-neoplastic and neoplastic serrated lesions.
: In this review, we examined the possibility that some halogenated organic derivatives were used in the primitive ocean at the beginning of life on Earth. Firstly, we described the existence of extraterrestrial halogenated molecules, then we studied their nonbiological syntheses on the present Earth, especially in volcanic environments. In order to demonstrate the diversity of today’s halogenated biomolecules, representative examples are given and the biosynthesis of some of them is summarized. Finally, we proposed two aspects of the chemistry of halogenated compounds that may have been useful en route to biomolecules, firstly the use of methyl chloride as the first methylation reagent, secondly the synthesis and use of α-chloro-carbonyl derivatives.
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