Chitosan (CS) and carboxymethyl cellulose (CMC), as ecofriendly biopolymers, were self-assembled to form a 3dimensional network and a hybrid material with ZnO nanoparticles (ZnO-CMC/CaCl2/CS). The designed system was used as a carrier for in-vitro release of 5-fluorouracil drug. The drug loading capacity and entrapment efficiency were investigated. Swelling behavior of the prepared systems and the cumulative release of the drug were studied at different concentrations of the raw materials at pH values of 2.1 and 7.4, which was emulated to the human gastrointestinal medium. The release kinetic data were fitted using the Korsmeyer-Peppas model to identify the diffusion mechanism. The prepared copolymers were characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.