The results of this study show that the prevalence of H. pylori infection seems to be significantly higher in patients with CSC than in control s. H. pylori infection may represent a risk factor in patients with CSC.
Method: prospective comparative interventional study on 85 patients with treatment naive classic, or predominantly classic, subfoveal choroidal neovascularisation (CNV) secondary to AMD. Patients were randomly assigned to Group 1 (IVB injections) and Group 2 (IVB plus low fluence PDT). In Group 2 the PDT with verteporfin was delivered with low fluence rate (300mW/cm 2 for 83seconds, 25 J/cm2). The follow-up was scheduled at 1-,3-,6-, 9-and 12-months.
Results:The eye without recurrence received a mean of 2.8 (Group1) vs 1.4 (Group2)IVB injections, whereas the eyes with recurrence received a mean of 3.2 (Group1) vs 2.2 (Group2) IVB injections. The difference in re-injections rate between the two Groups was statistically significant (P =0.03, ANOVA test). Visual acuity improvement was not statistically significant between the two Groups (P=0.31).
Conclusion:The combination of IVB with low fluence PDT for the treatment of classic or predominantly classic neovascular AMD works in a synergistic fashion with a significant reduction of IVB re-injections rate.4
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