A second revision of the Plio-Pleistocenic taxa of the family Tellinidae Blainville, 1814 of southern Europe is presented, 15 species are illustrated and discussed of which 3 described for the first time. For the genus Asbjornsenia Friele, 1886: Asbjornsenia pygmaea (Lovén, 1846); for the genus Strigilla W. Turton, 1822: Strigilla etrusca Brunetti M. & Della Bella, 2003; for the genus Bosemprella M. Huber, Langleit & Kreipl, 2015: Bosemprella incarnata (Linnaeus 1758), for the genus Fabulina Gray, 1851: Fabulina fabuloides Monterosato, 1884; for the genus Macomangulus Nordsieck, 1969: Macomangulus exiguus (Poli, 1791), Macomangulus tenuis tenuis (Da Costa, 1778); for the genus Oudardia Monterosato, 1884: Oudardia compressa (Brocchi, 1814), Oudardia strigilata (Philippi, 1844), Oudardia pliorecens n. sp. of the Tuscan-Emilian Plio-Pleistocene; for the genus Peronaea Poli, 1791: Peronaea planata planata (Linnaeus, 1758); for the genus Peronidia Dall, 1900: Peronidia albicans (Gmelin, 1791), Peronidia iberica n. sp. of the Spanish Early Pliocene, Peronidia intermedia n. sp. of the Italian Early Pliocene; Peronidia transiens (Cerulli-Irelli, 1909); for the genus Serratina Pallary, 1920: Serratina serrata (Brocchi, 1814, Renier m.s.). Some one specimen with open nomenclature are also reported and illustrated: Macomangulus sp. 1 of the Piedmont Early Pliocene.