Chinese dates fruit are generally used by the people of Indonesia as a fruit that has a fairly good nutritional value, namely every 100 g of Chinese dates fruit contain 79 kcal of energy, 1.2 g protein, 20.23 g carbohydrates, 250 mg potassium, 21 mg calcium, 23 mg. phosphorus, 0.5 mg iron, 3 mg sodium, 10 mg magnesium, 0.1 vitamin B6 and 69 mg vitamin C. Chinese dates fruit are foods that are rich in fiber, so they can lower blood cholesterol and cure chronic constipation. In addition, Chinese dates fruit are foods with good sources of potassium. Adequate potassium intake can lower blood pressure so that it can reduce the risk of cardiovascular disease. High iron content can also prevent anemia. The purpose of this study was to determine the differences in the content of iron, potassium, calcium, and sodium in fresh and boiled Chinese dates fruit fruit, and to determine the percentage decrease in levels after boiling. The method used in this study included dry digestion, then quantitative analysis of iron, potassium, calcium, and sodium was carried out using the Atomic Absorption Spectrophotometry (AAS) method, namely iron at a wavelength of 248.3 nm, for potassium 766.5 nm, to calcium 422.7 nm, and sodium 589.0 nm. The results showed that the iron content in fresh Chinese dates fruit fruit was (0.6687 ± 0.0084) mg/100 g and boiled (0.3285 ± 0.0127) mg/100 g. Potassium levels in fresh Chinese dates fruit fruit (657.9024 ± 0.4713) mg/100 g and boiled (158.6504 ± 0.2510) mg/100 g. Calcium levels in fresh Chinese dates fruit fruit were (47.3501 ± 1.1630) mg/100 g and boiled (26.3968 ± 0.5922) mg/100 g, and sodium levels in fresh Chinese dates fruit fruit (16.1272 ± 0.1543) mg/100 g and boiled at (13.4048 ± 0.1973) mg/100 g. The percentage decrease in mineral content in Chinese dates fruit fruit after boiling, for iron was 50.87%, potassium 75.88%, calcium 44.25%; and 16.88% sodium. Statistically different test of the average mineral levels of iron, potassium, calcium, and sodium using the T distribution, it can be concluded that fresh Chinese dates fruit fruit contain higher levels of iron, potassium, calcium, and sodium minerals than boiled Chinese dates fruit.
A B S T R A C TObjective: The present study was aimed to develop a spectrophotometric method by dual wavelength method in simultaneous analysis of irbesartan and hydrochlorothiazide on tablet preparations without separation. Irbesartan and hydrochlorothiazide are a group of anti-hypertensive drugs that are very effective and safe to use to reduce blood pressure and edema. These drugs often given in combination with these active ingredients can cause problems in quantitative analysis for the quality control of preparations. Methods: The study was carried out experimentally with a spectrophotometric method, one of which was dual wavelength method and then tested its validity based on validation parameters, namely linearity, accuracy, precision, LOD and LOQ and intraday and interday. Then, this method of irbesartan and hydrochlorothiazide in tablet preparations. Results: The results of the study were showed that the application of dual wavelength method on the concentration was carried out at λ 263.4 nm and 281 nm for irbesartan and at λ 243.4 nm and 247.6 nm for hydrochlorothiazide. The results obtained by irbesartan and hydrochlorothiazide on tablets were (108.04 ± 2.696) and (94.28 ± 4.48)% respectively, and with good precision and accuracy. Conclusions: The ultraviolet spectrophotometry method is dual wavelength method successfully applied for the determination of the concentration of irbesartan and hydrochlorothiazide in tablets.
Objective: This study aimed to evaluate the effects of papaya (Carica papaya L.) male flower hexane fraction (PHF) on cell cycle of colon adenocarcinoma (WiDr) cell and its combination index (CI) with doxorubicin.Methods: Flow cytometer and the CI were used to show the PHF on cell cycle of colon adenocarcinoma (WiDr) cell and to calculate the synergism potential, respectively. Result:The result showed that the PHF giving inhibition on cell cycle of colon adenocarcinoma (WiDr) cell in G0-G1, S, G2-M phase. Furthermore, the combination of PHF with doxorubicin in colon adenocarcinoma (WiDr) cell gave a strong synergistic effect with optimal concentration of 8 μg/ml-50 nM (PHF-Doxorubicin) with the IC score lower than 1. Conclusion:This study provides evidence that PHF could be a new potential co-chemotherapeutic agent with doxorubicin on colon adenocarcinoma cell.
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