The objective of the current research work is to investigate the in-vitro anti-bacterial and anthelmintic activity.The combined tri-herbal methanolic extract made up of equal quantities of leaves of Moringa oleifera, seeds of Terminalia chebula, and fresh bulbs of Allium sativum was evaluated for its in-vitro antibacterial and anthelmintic activity and was compared with its individual methanolic extracts of Terminalia chebula. The anti-bacterial activity was evaluated against gram neagative and gram positive bacteria. Streptomycin was used as a standard drug. The Anthelmintic activity was evaluated against Pheretima posthuma. Albendazole was used as a standard drug. The experimental results showed that triherbal methanolic plant extracts possess better activity on both microorganisms and earthworms. The combined activity of Moringa oleifera, Terminalia chebula and Allium sativum has been reported for the first time.
The background behind the delivery of drugs topically is to render localized action on the skin. Topical drug delivery employing conventional formulations such as ointment, creams suffers with lower uptake of drug due to its hydrophobic nature eventually leads to ineffective treatment. To overcome these issues, topical delivery of β-cyclodextrin-based nanosponges has opted, that facilitates the controlled drug release over a period of time. Topical drug delivery is an intriguing and persuading access to treat skin related infections/diseases owing to their lower risk of reactions a the systemic level duly contrasted with oral or parenteral drug administration and high drug level can be accomplished at the site of ailment. β-Cyclodextrin nanosponges (NS) are composed of permeable nanostructure material comprising of hyper cross-linked β-cyclodextrin system, ensures enhancement in solubility, provides desirable controlled release wider range of drugs by forming inclusion complexes, which diminish the recurrence portion of drug and maintain a distance from systemic absorption. Ketoconazole, an antifungal agent classified as BCS II, used to treat fungal infections and candidiasis. The stumbling block in attaining the effective therapeutic application and efficacy of ketoconazole is due to its moderate lipid solubility (Log P 4.35).
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