Drug addiction is a complex disorder that has been shown to have a genetic component like several other diseases. Finding any factor that is associated with higher risk of addiction tendency may influence the strategies of prevention and treatment of drug abuse and also provide an avenue of further research in genetics, immunology, and other related fields. This case-control study aimed at finding the frequency rate of ABO blood groups and Rhesus (Rh) factor among opioid dependents. Therefore, 249 opioid dependents referred to the Drug Quit center at Bam, Iran (case group) were compared with 360 blood donors referred to the Blood Transfusion Center (control group) in regard to the frequency of blood groups and Rh factor. The two groups were matched for demographic features. The odds ratio for AB blood group in addicts was 3.98 compared to non-addicts (p < .001) and the odds ratio of negative Rh in addicts compared to non-addicts was 4.27 (p < .001). According to the findings, in this population the frequency of negative Rh and AB blood group were significantly less than the predictive values. The relationship between opioid use and blood group type requires a cohort study eliminating all extraneous factors in order to be proved.
Background The development of lung cancer is a multifactorial process that involves the environmental and genetic factors. The mortality rate of this cancer is higher than breast, colorectal, and prostate cancers. In this study, we try to analyze the proteome of patients with Non‐Small Cell Lung Cancer (NSCLC) and compare it with the healthy samples. Methods This study has compared 30 lung tissue samples from patients with NSCLC and 30 healthy samples using proteomics and RT‐PCR. Hence, tissue samples were obtained from the surgical ward in sterile conditions, and then, protein extraction applied to them. At the next stage, two‐dimensional electrophoresis and mass spectrometry LCMS/MS were performed for protein isolation and sequencing, respectively. Results The proteome analysis identified more than 40 differences in proteomic pattern of normal lung tissues compared to lung tissues with NSCLC. Peroxiredoxin, Haptoglobin, and Alpha‐1 antitrypsin proteins were identified. Molecularly, it has also been shown that the two main proteins of Peroxiredoxin‐2 and Alpha‐1 antitrypsin were upregulated, and the expression of Haptoglobin protein was downregulated in cancer tissue. Conclusion The results of this study showed that there are some differences in term of protein content between the normal and cancerous lung tissues. Further studies are needed to evaluate these proteins that investigate whether these proteins can candidate as biomarkers to use in the early diagnosis of patients with NSCLC.
BackgroundWe pursued to find out the possible association of Methylene tetrahydrofolate reductase (MTHFR) A1298C gene polymorphism, blood homocysteine, vitamin B12, and folate with Coronary artery disease (CAD) in the study population in Guilan, north of Iran.Material and MethodsNinety patients with CAD and 76 healthy controls were evaluated. MTHFR A1298C polymorphism and its genotype frequency, the plasma level of homocysteine, vitamin B12 and folate were evaluated by using ARMS-PCR, ELISA, and Chemiluminescence methods, respectively.ResultsThe frequency of genotypes, A, AC and CC in CAD were 40, 35.6, 24.4%, respectively which was significantly different (p=0.016) from the control group that were 26.3, 57.9 and 15.8%, respectively. The serum level of vitamin B12 and folate in genotype A1298C were not statistically significant between two groups (p>0.05), however, the plasma homocysteine in patients with CAD was remarkably higher than the control group (p<0.001). Additionally, in CAD patients the plasma level of homocysteine in the AC genotype was significantly higher than the control subjects (p=0.005).ConclusionIt is thus concluded that MTHFR A1298C gene polymorphism is associated with CAD. It seems that the AC genotype of MTHFR A1298C polymorphism might have a protective effect on CAD.
Nowadays, the lack of happiness in organizational environments is one of the main problems for these organizations. In these organizations, organizational structures and management strategies should be looking for some tools and methods to perform the duties of the employee more effectively and increase the productivity through increasing monetary satisfaction, meeting vital needs and individually staff development in their organizations. Considering the issue, one of the newest and most efficient techniques is the creation of a happy organization with relaxation and satisfaction for staff by organizational management. The present study has been conducted to examine the effects of organizational happiness on the working life quality among Isfahan university staff. To do so, a sample of 200 employees was selected randomly. The data was collected through questionnaires. Data analysis was done by SPSS 18 and Amos 20. The results indicated that among university employees the quality of work life was highly affected by organizational happiness.
This study has been done on the relationship between organizational culture and organizational agility in Agricultural Bank of Chaharmahal and Bakhtiari Province; it is an applied and descriptive-field research also the study is correlational. The statistical population was all employees in Agricultural Bank of Chaharmahal and Bakhtiari Province and 260 subjects were selected as the statistical population by using Morgan table. After analyzing data, it was clear that the increase in each indicator of organizational culture leads to increase agility in Agricultural Bank of Chaharmahal and Bakhtiari Province.
The aim of the present study is to investigate the relationship between talent management strategy and career path in principals of schools in Shahr-e-Kord. The study is a descriptive-correlational one and its population includes all principals of high schools in Areas 1 and 2 of Shahr-e-Kord equal as 103 individuals in the academic year 2014-2015. A number of 81 principals were selected as participants via the simple random sampling and using Chochrane's formula. To measure talent management, the Sweem standard questionnaire and to measure career path, the Schaufeli standard questionnaire were used. The reliability coefficients for the questionnaires were calculated using Chronbach's alpha coefficients as 0.85 and 0.84 respectively. Data analysis was conducted using Pearson ISSN 2327-5499 2016 http://ire.macrothink.org 40 correlation coefficient and regression coefficient by SPSS. The results indicated that talent management strategy has a positive and significant correlation with principals' career path of principals of schools in Shahr-e-Kord. In addition, there is a direct and significant correlation between components of communication, performance management, training the staff and in acknowledgment of individuals with career path. International Research in Education
Background and objectives: Renal cell carcinoma (RCC) is one of the most leading causes of death among cancers. The therapeutic methods of RCC are surgery, immunotherapy, chemotherapy and biologic response modulators. Medicinal plants such as Nigella sativa (N. sativa) also are used for the treatment of cancer. Therefore, in this study the effect of aqueous fraction of N. sativa was investigated on percentage of live cells in the human renal carcinoma cell line (ACHN) and normal human renal epithelial cells (GP-293). Materials and Methods: Aqueous fraction of N. sativa obtained from %70 hydro-alcoholic extract after discarded of n-Hexane, dichloromethane, ethyl acetate, N-butanol fractions. In this study two cell lines including carcinoma cell line ACHN and normal cell line GP-293 were used. Cells were seeded in 96 well plates and were treated with various concentrations of aqueous fraction and cell viability was calculated with MTT after 24, 48 and 72 hours. Results are presented as Mean ± SEM. Statistical analysis was performed by using SPSS. One-way ANOVA test was applied for the statistical analysis of the data. Results: our results showed aqueous fractions of N.sativa didn't significant effect on percentage of live GP-293 cells in certain dose and time but its effect on percentage of live ACHN cells is significantly higher than control group and GP-293 cell line in dose and time-dependent manner. Conclusion: It was concluded that the aqueous fraction of N.sativa has cytotoxic effects on ACHN cell line but didn't has any significant effect on GP-293 cell line.
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