RNFL thickness in ALS patients is reduced compared to healthy controls. OCT probably could serve as a marker of neurodegeneration and progression of the disease in ALS patients. RNFL thickness is different among the right and left eyes of ALS patients pointing to the fact that asymmetric CNS involvement in ALS is not confined to the motor system.
period, with 738 CAS procedures in 632 patients included after exclusion criteria. Overall restenosis rate was 17%, with a 14% restenosis rate at 2 years-time. Multivariable analysis demonstrated former/current smoking status (OR=2.1 [95%CI 1.2-3.9]), moderate contralateral stenosis (OR 3.0 [95%CI 1.4-6.7]), severe contralateral stenosis (OR3.0 [1.4-6.3]), and residual stenosis (OR 454 [95% 85-2413]) were associated with restenosis. AUC for the multivariable model was 0.78. Cutpoint degree for residual stenosis was ~30%, where there was a 9% and 35% rate of restenosis in those less than, and greater than, 30% residual stenosis, respectively (figure 1). Conclusion We present the largest single-center data in the US to date on carotid artery stenosis treated with CAS, and factors associated with restenosis. Residual in-stent carotid stenosis and smoking history were independent predictors. Maximizing treatment of initial stenosis within stent for carefully selected patients and aggressive smoking cessation education are important steps in preventing future carotid restenosis.
rates of favorable functional outcomes compared to those managed medically (19.19% vs. 10.10%, p = 0.090; OR, 2.11 [95% CI,]; p = 0.095). TPA was utilized at a higher rate in patients receiving EVT compared to medical management (35.35% vs. 17.17%, p = 0.005). There were higher rates of intracerebral hemorrhage (ICH) in the EVT group (20.20% vs. 8.08%, p = 0.025). Inpatient mortality rates were not different between the two groups (20.20% vs. 18.18%, p = 0.730). Conclusions In this matched NIS analysis of patients treated for ischemic stroke with a concomitant COVID diagnosis, we demonstrate that EVT trends towards, although nonsignificant, higher rates of favorable functional outcomes when compared to medically managed patients.
minutes with the portable MRI system, largely in part due to the expedited MRI screening system, patient prep, and time efficient intrahospital transfer to the unit. However, this isn't without limitations that come with the portable MRI system including a lower image resolution and limited imaging sequences including a lack of perfusion imaging and the ability to evaluate vascular pathology. Further statistical analysis is in process and will be provided at the time of the conference. Conclusion Portable MRI is a promising innovation with the aim to expand patient access and improve diagnostic times so that critical and potential lifesaving imaging diagnoses can be promptly treated with the urgency that is required. While initial analysis provides evidence that portable MRI has advantages over conventional MRI systems including workflow efficiency and improved patient imaging times, this will need to be compared to the unfortunate negative drawbacks of lessened image resolution and limited imaging sequences that come with the convenience of portable MRI systems. If the hypothesis is further corroborated, then future studies could be aimed at investigating and comparing the various treatment protocols of initial stroke imaging through the emergency department with the incorporation of this user-friendly and readily available technology. Disclosures O.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.