Immunoreactive calcltonm (CT) is present in liver. This could represent hormone synthesized by liver cells, degraded or bound to spectfic receptors reported in this organ. We report here that the calcitonin gene IS expressed in liver We proved this by demonstrating.by PCR amplification using spectfic primers, the presence of calcitonin messenger in human liver and m primary cultures of human hepatocytes and detected by radioimmunoassay CT in hepatic tissues and cells. The synthesis of hormone by liver that also possesses specific receptors for CT favors the presence of an autocrine or paracrme system mvolvmg calcitonin in thts organ.Autocrine: Paracrine; Biosynthesis; Calcitonin mRNA (human liver): PCR
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