Sialic acids as terminal units of the oligosaccharide chains of numerous glycoproteins and glycolipids are involved in many biologically important function^',^). The amount of sialic acids important for the function of these molecules +) On study leave from the Department of Chemistry, Shivaji Uniresults from a balance between the incorporation of an activated sialic acid into a matrix and its release by sialidases. In order to gain more insight into the structural requirements for the activity of these enzymes, many non-natural sialic acids have been prepared over the last years. Structural variations have been performed at C-g4) and C-45-7) and evaluated with respect to their activation by CMP-sialate versity,
Synthesis and Structural Elucidation of (±)-3,4-Dihydrocoumarins by 2D-NOESY Spectrum. -TFA-mediated condensation of substituted phenols with cinnamic acids provides 3,4-dihydrocoumarins (III) (14 examples). Their structures are confirmed by 2D-NOESY spectroscopy. -(SHUKLA, M. R.; PADIYA, K. J.; PATIL, P. N.; SALUNKHE, M. M.; Indian J. Chem., Sect.
The sodium salts of 8‐epi‐, 7‐epi‐, and 7,8‐bis(epi)‐N‐acetylneuraminic acid (Ia), (Ic), and (Ib), resp., and the title deoxy derivatives are synthesized analogously to (Ib).
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