The electron mediator properties of three subphthalocyanines (SubPcs) [hexa-chloro boron subphthalocyanine (ClSubPc), tri-tert-butyl boron subphthalocyanine (t-BuSubPc) and hexa-phenoxy boron subphthalocyanine (PhOSubPc)] in Tyrosinase and Laccase biosensors (deposited on ITO glass) for the detection of catechol and hydroquinone were evidenced. A particularly remarkable performance was observed in the PhOSubPc-Tyr sensor, which takes account of the p-p interactions between subphthalocyanine rings and the active sites of the enzymes. Mediated electron transfer between redox enzymes and the ITO electrode improved the limits of detection by one order of magnitude, reaching 10 À7 molÁL À1 values. Studies at increasing scan rates confirmed the improvement of the charge transfer rates caused by the presence of the SubPcs. A bioelectronic tongue formed by an array of the SubPc based biosensors has been able to discriminate red wines according to their Total Polyphenol Index.

Fused pyrimidine derivativesFused pyrimidine derivatives R 0515 Synthesis and Pharmacological Activity of 1-and 10-N-Substituted 1(10),2,3,4-Tetrahydropyrimido[1,2-a]benzimidazoles. -A variety of new N-substituted pyrimidobenzimidazoles [cf. (V), (VIII), (X)] are synthesized and screened for their pharmacological properties. Some derivatives possess spasmolytic, anti-aggregating and/or hypotensive activity. -(ANISIMOVA, V. A.; OSIPOVA, M. M.; SPASOV, A. A.; TURCHAEVA, A. F.; DUDCHENKO, G. P.; LARIONOV, N. P.; KOVALEV, S. G.; Khim.-Farm. Zh. 36 (2002) 9, 11-16; Nauchno-issled. inst. fiz. org. khim., Rostov. gos. univ., Rostov-na-Donu 344090, Russia; Russ.) -Koehler 04-154

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