OBJECTIVE. Unenhanced CT scanning canreliablycharacterize incidentally detectedadrenal masses when observers use density measurements of the adrenal gland. However, con troversyexistsasto theoptimaldensitythresholdrequiredto differentiatebenignfrom malig nant lesions. This study attempts to establish a consensus by performing a pooled analysis of data found in the CT literature.
MATERIALS AND METHODS. TenCT reports wereanalyzed, fromwhichindividualadrenal lesion density measurements were obtained for 495 adrenal lesions (272 benign le sionsand 223 malignantlesions).Thresholdanalysisgenerateda rangeof sensitivitiesand specificities for lesion characterization at different density thresholds.
RESULTS.Sensitivity forcharacterizing a lesionasbenignranged from47% ata threshold of 2 H to 88% at a threshold of 20 H. Similarly, specificity varied from 100% at a thresh old of 2 H to 84% at a threshold of 20 H.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.