The inhibition of LTG metabolism by VPA was shown to have a marked effect on LTG kinetics. This inhibitory effect was complicated further by inter-patients variation in body weight and gender. This emphasizes the importance of continuous monitoring of LTG serum concentrations on an individual basis. Accordingly, if the use of potentially interacting drugs cannot be avoided, adverse reactions can be minimized by dose adjustments guided by careful monitoring of clinical response and measurement of LTG serum concentrations.
Raman spectra of Mg(CIO,),-NaNCS-H,O mixtures were analysed as a function of the concentration ratio of the components at ambient and elevated temperatures. The strong perturbation of the thiocyanate spectrum observed in the regions of the v, and v3 vibrations is interpreted in terms of complex formation. Band intensity measurements of resolved bands gave evidence for two complex species: (MgNCS]' and [Mg(NCS),], the former being discernible over the whole concentration range studied. The variations in the spectrum of the Td perchlorate ion at very low water-to-salt molar ratios are explained as indicating a coordination of C10,-unit and lowering of the symmetry of C,, .
Raman spectra have been used to investigate the cation-solvent interaction in acetone solution of Mg(CI0,)2. Analysis of the bands of C=O and C-C valence vibrations of acetone and the totally symmetric vibration of CIO,' ion led to the identification of different magnesium-acetone associations. The stability of the formed solvate species has been tested by adding NaSCN to solution. It is found that all bands arising from the solvated acetone molecules to the Mg2' ion are changed in the presence of NaSCN and the new bands, attributed to the other species, occur. Formation of the magnesium-isothiocyanato complexes in solution has been supported by the analysis of the symmetric stretching v, (C-N) vibration of the SCN' ion.
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