We did not find any major effect among the explored members of the NFkappaB pathway in RA susceptibility. However, it is possible that variation in the IKBKE gene could have a small effect that requires replication in additional studies.
None of the SNP in CFH and CD209 showed evidence of association with RA. We did not replicate the association of eotaxin-3 with RA described in Koreans, or that of the MHC2T SNP.
Background
Videocapillaroscopy allows for the detection of changes in microcirculation characteristic of connective tissue diseases. Differences in the capillaroscopic findings have been found between healthy adults and healthy children. Currently there is no defined capilaroscopic pattern in JIA.
Objective
Describe periungual capillaroscopy findings in a series of children with JIA.
Materials and Methods
Medical records of patients less than 18 years old were reviewed. We identified 14 patients, current mean age of 11.35, and predominantly female. All videocapillaroscopy were performed by the same rheumatologist.
Results
Microvascular alterations were found in 12 patients. All had tortuous capillaries, 4 had bushy morphology and 1 had twister morphology. Venus plexus was very visible in 9 patients. Dilated capillaries were found in 6 and 6 other patients showed a lower capillary density. Data analysed by JIA forms showed more frequent capillary dilation in the oligoarticular and enthesis forms and less capillary density in the oligoarticular form.
Abstract A9.8 Table 1 Data by type of JIA
JIA Form
Abnormal capillaroscy
Abnormal morphology
Bushy
(neovessels)
Twister
Low density capillary
Dilation
Monoarticular (2)
0
0
0
0
0
0
Oligoarticular (5)
5
5
1
0
3
0
Polyarticular FR- (3)
3
3
1
1
1
3
Enthesis related (3)
3
3
2
0
1
3
Psoriatic (1)
1
1
0
0
1
0
Conclusions
In JIA, only nonspecific changes have been described, such as tortuosity and elongation of capillaries, micropetequias and increased venular plexus visibility, these changes are more frequent in polyarticular JIA and patients with positive RF or ANA. In the overall assessment of our series, we found morphological alterations in all children (capillary tortuosity) and excellent visibility subpapilar venous plexus and disorganisation disorganised bed in a high percentage of children with JIA regardless of subtype. In all children with polyarticular JIA and enthesitis related, capillary dilation was observed. No increased Microvascular alterations in children with ANA + , or in which they maintained clinical activity. Thus, our study confirms the existence of nonspecific JIA and highlights the possibility that capillary dilation is a specific finding in polyarticular JIA and enthesitis related, although the sample is small and will need to conduct studies that clarify this possibility and can help determine whether it may be clinically useful.
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