We describe the construction of retroviral plasmid vectors lation gives rise to a bicistronic mRNA and two indein which two genes are linked by a minimum of 96 nucleopendent protein products. The system offers advantages tides encoding the 2A sequence from the picornavirus footto other alternative ways to create polycistronic mRNAs and-mouth disease virus (FMDV). Transcription and transand can be used in gene therapy delivery vectors.

A new strategy for cancer gene therapy has been substrate, linamarin, followed by cell death. We show that developed using a plant gene which encodes the enzyme, the system can eradicate very large intracerebral gliomas linamarase, that hydrolyzes the cyanogenic glucoside subin vivo helped by a cyanide bystander effect. Animals strate, linamarin, into glucose, acetone and cyanide. Retroshowing a total regression of the tumor by magnetic resonviral vectors that carry linamarase as a potential killer-suicance imaging (MRI), do not show other appreciable toxic ide gene cause a marked sensitization to the innocuous effects.

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