In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.
Abstractmagnified imageTwo new galloylated flavonoid glycosides, quercetin‐3‐O‐(3″‐O‐galloyl)‐β‐glucopyranoside (1) and quercetin‐3‐O‐(3″‐O‐galloyl)‐β‐galactopyranoside (2) were isolated from the aerial parts of Geranium stepporum along with the four known flavonoids, quercetin 3‐O‐β‐glucopyranoside (3), quercetin 3‐O‐β‐galactopyranoside (4), quercetin 3‐O‐(6″‐O‐galloyl)‐β‐glucopyranoside (5) and quercetin 3‐O‐(6″‐O‐galloyl)‐β‐galactopyranoside (6). The structure elucidation of the isolated compounds was accomplished by spectroscopic methods (UV, 1D‐ and 2D‐NMR, and ESI‐TOF‐MS).
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