A variety of aryllithium compounds can be easily obtained via a direct heteroatom-facilitated lithiation.' The coordination of the electron-deficient metalating agent with the nonbonding electrons of the substrate heteroatom has been proposed as the initial step in these reactions, but experimental proof for this is not yet available. ' We have studied the lithiation of mono-2 and 1,3-bis(dia1kylamino)methylbenzene~~ as representative substrates and report here the structure in the solid state of a new tetranuclear aryllithium cluster, Li4[C6H4-2-(CH2NMe2)]4 (la) containing the first example of a face-center bonded aryl group. We include I3C (natural abundance) N M R data that reflect the structures of la and lb and related Li2[C6H3-2,6-(CH2NMez)2]z (2) in toluene and toluene-THF mixtures. Compound la, Li4[C6H4-2-(CH2NMe2)] 4, crystallizes slowly (48 h) from an ether-hexane solution containing an exact equilimolar mixture of n-butyllithium and N,N-dimethylbenzylamine (see eq 1). Crystals of la are tetragonal with space group Za with 16 molecules in a unit cell of dimensions a = 18.5 13 (1) and c = 10.187 (1) A. his stimulating interest. Registry No. la, Supplementary Material Available: Listings of positional and thermal parameters for Li4[C6H4-2-(CH2NMe2)I4 and of bond distances and bond angles (14 pages). Ordering information is given on any current masthead page. (29) Seebach, D.; Siegel, H.; Gabriel, J.; Hiissig, R. Helv. Chim. Acta (30) Clark, T.; Chandrasekhar, J.; von Ragut Schleijer, P.

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Obsessive-compulsive symptoms (OCS) are frequently reported in patients with schizophrenia and have been associated with subjective distress and higher impairment. Recent studies suggest fluctuation in co-occurring OCS and associations with the course of psychotic symptoms. Current evidence is limited by few studies with long assessments intervals and a sole focus on between-subject comparisons. The aim of this study was to specifically investigate co-variation of symptom domains over time within individuals. Patients with a psychotic disorder (n = 56) and un-affected siblings (n = 49) completed monthly assessments of clinical and subclinical symptoms over 6 months. Mixed-model multilevel analyses examined the variability and relationship between OCS and positive, negative, and depressive symptoms on the between- and within-subject level. Symptom domains were associated across subjects and assessment times, in patients and siblings, with the strongest association between OCS and (subclinical) positive symptoms. Within-subjects, substantial variability and co-variation of all symptom domains was found. Particularly, between-subject differences in positive symptoms and within-subject change in depressive symptoms predicted subsequent OCS in patients 1 months later. This is the first prospective study disaggregating between and within-subject associations between co-occurring OCS and symptom cluster of psychosis. Differences on these two levels suggest different underlying mechanisms. The association between depressive symptoms and subsequent increase/decrease of OCS within patients may have important treatment implications.

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