A575Objectives: Cataract surgery is the most frequently performed surgical operation in the EU and Nd:YAG laser capsulotomy, a procedure to treat posterior capsular opacification (PCO), is the most commonly reported complication after cataract surgery. The aim of this study was to investigate the incidence of Nd:YAG laser capsulotomy reported in the literature for hydrophobic monofocal AcrySof® IOLs versus non-AcrySof monofocal acrylic IOLs (hydrophilic and hydrophobic). MethOds: Randomized controlled trials (RCTs) were identified through a systematic literature search using Embase®, MEDLINE®, MEDLINE®-In Process, and Cochrane platforms (January 1996 through July 2016). Meta-analyses evaluating the incidence of Nd:YAG capsulotomy at ≤ 1 year, between 1 and 2 years, and > 2 years were conducted comparing AcrySof® IOLs versus non-AcrySof hydrophilic and hydrophobic acrylic IOLs. Subgroup analyses were also conducted between groups. Results: 17 RCTs met the inclusion criteria and were included in the main analysis. AcrySof® IOLs had significantly lower Nd:YAG capsulotomy rates at 1-2 years post-surgery (OR, 0.09; 95%-CI, 0.05 -0.17; p< 0.05) and > 2 years (OR, 0.33; 95%-CI, 0.16 -0.69; p< 0.05) compared to non-AcrySof acrylic IOLs. In the subgroup analysis, AcrySof® IOLs had significantly lower Nd:YAG capsulotomy rates compared to hydrophilic acrylic IOLs at 1-2 years (OR, 0.09; 95%-CI, 0.04 -0.17; p< 0.05) and > 2 years (OR, 0.09; 95%-CI, 0.02 -0.49; p< 0.05). A similar trend was observed vs. non-AcrySof hydrophobic IOLs at > 2 years post-surgery. However, this analysis was limited to a low number of studies (n= 3) and the observed difference did not reach statistical significance (OR, 0.60; 95%-CI,0.25-1.43; p= > 0.05). cOnclusiOns: AcrySof® IOLs are associated with a significantly lower incidence of Nd:YAG capsulotomy compared to non-AcrySof acrylic IOLs (hydrophilic and hydrophobic) and hydrophilic acrylic IOLs at ≥ 2 years, postcataract surgery. Regarding the incidence of Nd:YAG capsulotomy, further research comparing AcrySof® IOLs to non-AcrySof hydrophobic acrylic IOLs is warranted.
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