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Cellulose triacetate and tribenzoate coated on macroporous silica gel showed excellent capabilities of chiral recognition as packing materials for high-performance liquid chromatographic resolution of various enantiomers. Chiral recognition by the cellulose triacetate was different from that by the microcrystalline cellulose triacetate.

Electronic and structural properties of phosphorus terminated structure of Ni 2 P(0001) surface(Ni 3 PP) are investigated by density functional theoretical (DFT) calculation. Phosphorus adsorption largely stabilizes the Ni 2 P(0001) surface by creating Ni-P bonds on the Ni trimer. Atomic hydrogen can adsorb on the topmost P site but its adsorption energy is much lower than its adsorption energy on the Ni trimer site of Ni 3 P 2 surface. Our results suggest that the Ni trimer is the key factor for high catalytic activity.Nickel phosphide (Ni 2 P) shows a high catalytic activity for the hydrodesulfurization[1] and other hydrotreatment catalyses towards hydrodenitrogenation and hydrodeoxidation and so on.[2] The key issue to understand the hydrogenation reactions is interaction between hydrogen with Ni 2 P surface in an atomic level. The bulk structure of Ni 2 P is composed of two different layers with different composition, Ni 3 P 2 and Ni 3 P 1 , aligning alternately along the [0001] direction as shown in Figure 1(a). Rodriguez et al. showed that Ni 3 P 2 surface was more stable surface than Ni 3 P 1 surface and they discussed the hydrogen adsorption properties on the Ni 3 P 2 surface.[3] However, scanning tunneling microscopy (STM) and low energy electron diffraction (LEED) studies on the Ni 2 P(0001) have revealed that the Ni 2 P(0001) surface is mainly (about 80 %) covered with phosphorus on the Ni three fold site of Ni 3 P 2 surface after 953 K annealing under UHV conditions with minor amount of uncovered Ni 3 P 2 surface. [4][5][6] This new phosphorus covered surface is called as Ni 3 PP surface. Similar phosphorus terminated surface was reported on the reconstructed (10-10) surface by STM observation [7]. The phosphorus termination of the surfaces were supported by photoemission spectroscope (PES) study. [8][9][10] Moreover, recent in situ XAFS studies show that the adsorption of sulfur on the Ni 2 P creates the active phase. [11][12][13] Therefore the chemically modified Ni 2 P surface is interesting not only the fundamental problem but also the catalysis applications.In the present study we have explored the density functional theoretical (DFT) work on the Ni 3 PP surface to reveal the mechanism of P-covered surface formation and its hydrogen adsorption properties in comparison with the Ni 3 P 2 .DFT calculations were performed using the Vienna abinitio Simulation Package code (VASP 5.2.12).[14-16] The Perdew-Burke-Ernzerh exchange-correlation functional with a generalized gradient approximation [17,18] was used. Projector-augmented wave approach (PAW) [19,20] have been used together with plane wave basis sets. The optimized bulk Ni 2 P lattice constants were a = b = 0.5876 nm, c = 0.3365 nm, α = β = 90°, γ = 120°. The Ni 2 P(0001) surface was modeled with 12 atomic-layers periodic slab with a ca. 3.5 nm vacuum layer. The chemical formula of Ni 3 P 2 and Ni 3 PP are Ni 36 P 18 and Ni 36 P 19 , respectively. The kinetic energy cutoff of 300 eV was used and the Brillouin zone was sampled by a 4 × 4 × 1 Monk...

Optical resolution of five β-adrenergic blocking agents (β-blockers) alprenolol, oxyprenolol, propranolol, pindolol, and atenolol was examined by HPLC on 13 chiral stationary phases composing of cellulose triphenylcarbamate derivatives. All β-blockers were completely resolved on a cellulose tris(3,5-dimethylphenylcarbamate) column.

Tyrosine kinase inhibitors of epidermal growth factor receptor (EGFR) improve the survival of patients with lung adenocarcinoma, and determine the EGFR mutation status before treatment is necessary. In contrast to biopsy samples, cytological specimens are obtained less invasively and are useful for EGFR mutation analyses. Recently, novel antibodies against two major EGFR mutations were developed: SP111, which is specific for the E746-A750 deletion in exon 19; and SP125, which is specific for the L858R mutation. To the best of our knowledge, no study has evaluated cytological specimens using the two novel antibodies, thus their specificity and sensitivity were examined in surgical resection, and cytological lung adenocarcinoma samples in the present study. Previous screening for EGFR mutation status by molecular testing identified delE746-A750 in 3 cases and the L858R mutation in 7 cases; the other cases did not have the L858R or the delE746-A750 mutation. Using a four-grade scoring system (score 0 to 3+), the immunohistochemistry (IHC) and immunocytochemistry (ICC) results were compared with those of molecular testing. Using a score of ≥2 as positive, IHC and ICC using SP111 demonstrated sensitivities of 100 and 33.3%, and specificities of 100 and 100%, respectively. IHC and ICC using SP125 revealed sensitivities of 100 and 71.4%, and specificities of 100 and 100%, respectively. Therefore, screening for EGFR mutations by ICC may facilitate therapeutic decision-making, particularly in medical centers that are unable to perform molecular testing.

Trialkylsilyl ethers of 4-hydroxy-2-cyclopentenone, which are the key compounds for the syntheses of prostaglandins, were completely resolved on chiral HPLC columns packed with cellulose triphenylcarbamate derivatives.

DBU (3.0 equiv) toluene, reflux R N OH 20 examples up to 93% yield O P OPh PhO N 3 DPPA (1.5 equiv) R N H N N NAbstract A novel method for the synthesis of 5-substituted 1H-tetrazoles using diphenyl phosphorazidate (DPPA) has been developed. Aromatic and aliphatic aldoximes underwent cycloaddition to afford the corresponding 5-substituted 1H-tetrazoles with ease and efficiency.