Nuclear and radiation safety remains one of the most important components of the national security of our country. The increasing requirements for the medical care system in the Armed Forces of the Russian Federation in case of peacetime acute radiation injuries are due to the impossibility of completely eliminating the risks of radiation emergencies as a result of natural disasters, industrial radiation accidents and the threat of nuclear terrorism. The peacetime three-level system of medical support in the Armed Forces of the Russian Federation has been developed. It is designed to guarantee the first aid, primary predoctor care, primary doctor care and primary specialized health care for victims of acute radiation injuries by medical units, formations and organizations in the territorial zone of responsibility. In 2017 it was completed a research work "Improving the organization of therapeutic care in acute radiation injuries at the stages of medical evacuation in radiation accidents". An analysis of medical service capabilities to provide specialized, high-tech medical care in radiation injuries showed the relevance of the clinical base development in military medical organizations and the importance of interaction with radiological medical centers of other ministries, agencies and services. The solution of these tasks will be facilitated by the creation of a specialized infrastructure on the basis of military medical organizations of the district (fleet), which is providing necessary conditions for the provision of medical assistance to victims of the radiation emergency.
The earlier studies of some authors of this paper showed that, contrary to the theoretical expectations, the mortality rate of cancer patients treated with radio-or chemotherapy had not been changing monotonically with age, but experienced several repetitive cycles during the last 2-3 years of life [ESRB, 2004]. As the number of cases in this earlier investigation was limited, we tested the statistical validity of this finding using different data sets with a larger number of cases. For these purposes we investigated the survival curves for i) 3 different stages of breast cancer (T1N1-2M0 ,T2N1-2M0 ,T3-4N1-2M0) extracted from the Finnish Cancer Registry that covered a time period 1945-79(n=333) and ii) 12 different age groups of breast cancer (covering age interval 30-89 years) extracted from the U.S. Surveillance, Epidemiology and End Results (SEER) Registry (n=83536). Parametric methods were used to describe the survival curves by exponential functions (i.e., using one-compartment models with constant death rate k, or two-compartment models with k1 and k2 as death rates in each compartment), and harmonic function allowing for estimation of repetition period Tcycle of quasi-sinusoidal disturbances of the monotonic dumped exponential path. Nonparametric methods such as smoothing, spectral analysis, and a series of non-parametric tests were used to confirm the findings of parametric analyses and investigate statistical significance of the estimated periods. We found that there exists a life span region of 0-40 months in which fluctuations in survival curve and respective hazard rates are detectable. The period of such fluctuations, Tcycle, is in reciprocal relation with k value and varies within 5 -more, then 40 months. The Tcycle varies dependent on diagnosed cancer, or age at diagnosis. The Tcycle shows a maximum of 40-54 years-old subjects being described as n-order polynomial function of age. The Tcycle is shortening along as cancer stages increase. In the cases when the survival curves allow for decomposition into two compartments, associated with different rates of mortality k1 and k2, the Tcycle can be associated with k corresponding to dominant compartment. In view of this, the phenomenon of stable fluctuations in survival can be understood if to assume an existence of certain physiological processes correlated with or even defined by the probability of death. We formulate respective hypotheses about the relation of this phenomenon with regular predeath instabilities in physiological systems and first of all in stem and progenitor cells compartments of the hematopoietic system.
We've reported earlier about spontaneous regular fluctuations of concentration of the CD34 + -cells recorded in the blood of Chernobyl cleanup workers (CUWs) in remote period of time and about an opportunity of artificial growth of the previously mentioned parameter by transcutaneous vibrational impact on awake medullary hemopoiesis zones. The current research aims at studying interfacing of CUWs' exercise performance indices and of the amount of haemopoietic stem cells in their peripheral blood after vibroacoustic influence. Materials: A random sampling of CUWs under long-term dispensary observation (40 male patients, aged 50 on average) have been examined under dispensary conditions. Methods: A course of vibroacoustic mobilization of autologous haemopoietic stem cells into the bloodstream from the bone marrow haemopoietic zones has been conducted with the purpose of correction of CUWs' psychosomatic condition. The CUWs' exercise performance has been examined via veloergometric exercise ECG testing before the modulation course and 3 to 6 months later on. CD34+ -cell subpopulation in peripheral blood was estimated by laser cross flow-cytometry method (FACScan, Beckton-Dickinson) with monoclones (DAKO, BD) before and right after the end of the modulation course. Results: For a cluster of patients examined, certain increase in the number of CD34 + -cells in the blood right after the end of the modulation course has been discovered. Dynamic tracking (3 to 6 months) of this cluster has revealed certain increase in the number of patients capable of fulfilling the exercise ECG test; maximal oxygen uptake for all the patients of this cluster has also shown certain increase in the same period of time. On the contrary, increase of the reviewed indices were uncertain for those patients, who did not demonstrate any growth of the amount of CD34 + -cells right after the modulation course. Conclusions: For a distinct cluster of examined patients, interfacing has been discovered in between growth of the amount of CD34 + -cells into their peripheral bloodstream right after the course of noninvasive vibroacoustic modulation and increase of the showings of their exercise performance in 3 to 6 months.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.