The aim of this study was to assess the impact and effectiveness of vaccination among the pregnant population on maternal, obstetrical, and fetal outcomes. Material and Methods:In this study we included all parturients tested positive for COVID 19 during pregnancy and who needed hospitalization at any stage of gestation. Then, patients were divided into 2 groups according to their vaccination status: M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o nThe Vaccinated Group: included pregnant women with completed vaccination by receiving 3 doses of mRNA Vaccine or 2 doses on condition that the second dose received within the last 6 months.The non-vaccinated group: included pregnant women who had no vaccination against COVID 19.We collected data about obstetrical and fetal outcomes with 3 months of follow-up.Results: 145 parturients were admitted for COVID 19 in the maternity of Sfax in Tunisia. The vaccinated group included 45 patients and the non-vaccinated group included 100 patients. Demographic parameters were comparable in both groups. The vaccination reduced the rate of hospitalization in Intensive care units from 23% to 4.3%; p<0.001. Cesarean section delivery was seen in 56 cases from 76 patients who delivered while infected (73%) versus 11 cases from 33 who delivered in the vaccinated group (33.3%) with p<0.001. The vaccination reduced the risk of prematurity from 35% to 6.6% with p<0.001. No cases of vertical transmission were noted in either group. Conclusions:Pregnant women seem to be protected from severe forms and severe complications of COVID 19. Obstetrical and neonatal outcomes appear to be improved with vaccination.
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