Introduction: Breast cancer is the form of cancer that occurs in the breast cells. After skin cancer, breast cancer is considered to be the most common cancer diagnosed in women. The number of deaths associated with this disease was increased in case of lack of early detection. Tribulus terrestris is an annual herb belonging to the Zygophyllaceae family. Flavonoids, alkaloids, and saponins are some of the main phytoconstituents of the herb. They are known for their pharmacological actions such as anti carcinogenic, anti inflammatory, antimicrobial, antioxidant properties. Aim: The aim of the present study is to evaluate the antitumor activity of ethanolic extract from Tribulus terrestris in MCF-7 human breast cancer cells. Materials and Methods: The effect of Tribulus terrestris on cell viability was measured by MTT assay carried against breast cancer cells and morphological changes were investigated with phase contrast microscopy to confirm its antitumor activity. Results: the cell viability assay results indicate that 24hrs treatment with ethanolic extract of significantly reduces the cell viability in dose dependent manner. At 40 μg/ml of the Tribulus terrestris extract inhibits 50% cell viability and it has been fixed as IC50 value for further Tribulus terrestris experiments. Conclusion: From the results, the extracts were cytotoxic to the human breast cancer cell and it might be a good therapeutic value for further investigations needed to understand the mechanisms to develop antitumor agents.
Introduction: Acinetobacter baumannii is a gram negative coccobacilli often considered as a nosocomial pathogen and as an opportunistic pathogen in immunocompromised patients. It is considered to be multi-drug resistant and a potent bacteria forming vital biofilms. Ptk which is protein tyrosine kinase is a protein coding gene involved with the synthesis of capsular polysaccharide. Ocimum sanctum is a perennial plant belonging to the Lamiaceae family. Tulsi and holy basil are the common names of this plant. In-silico docking approach method is much more convenient and cost effective to assess the bioactive properties of the natural drugs against any target ligands. Aim: The aim of the study to assess the inhibitory effect of Ocimum sanctum bio-compounds against ptk of Acinetobacter baumannii using a computational approach. Materials and Methods: Retrieval of the structure of ptk was followed by Ligand preparation and optimisation. Further drug likeliness was assessed using Molinspiration parameters, docking simulations and visualisation for the binding energy and hydrogen bonds. Results: Among the bio compounds of O.sanctum, benzofuran is selected as an active inhibitory compound with -11.12 as its binding energy showing a high affinity. Conclusion: The findings of the present study documents benzofuran as the promising candidate to design novel drugs from O.sanctum and to target the ptk of A.baumannii. However further experimental validation must be done to observe its efficacy and safety in the treatment of nosocomial infections caused by A.baumannii.
Introduction: Phyllanthus emblica commonly known by names such as Indian gooseberry, amla belongs to the Phyllanthaceae. The plant is used as a medicine and tonic which is highly nutritious and forms an important dietary source of vitamin C and amino acids. Honey is rich in iron which helps in boosting the hemoglobin content in blood by increasing their synthesis. Complete blood count (CBC) is an array of tests to evaluate the cells in the blood which are the red blood cells, white blood cells, platelets. Aim: The aim of the study is to compare the effect of Phyllanthus emblica (Indian Gooseberry) with and without honey on hemoglobin, RBC (Red Blood Cell) and PCV (Packed cell volume) among adolescents. Materials and Methods: Ten adolescents including both male and female were selected as subjects for the study. The first group of subjects were categorised to consume gooseberry alone and the second group of subjects were categorised to consume gooseberry along with honey. After 15 days, CBC was taken for the subjects of both groups to analyse the results. Independent ‘t’ test was applied to evaluate the significance of clinical trials performed in two groups. Results and Discussion: The participant history included fatigueness, pallor, menstrual history, blood pressure, pulse. There is an increase in the mean value of Hb (Hemoglobin), RBC (Red Blood Cell), HCT (Hematocrit), MCV (Mean corpuscular volume), MCH (Mean corpuscular hemoglobin) and RDW (Red cell distribution width). Independent statistical analysis showed that p value is not significant as all the values are not <0.05. Conclusion: The present study concludes that gooseberry with honey supplementation has shown better results than gooseberry supplementation but it is not statistically significant. It is evident that gooseberry has nutritive and restorative properties. Daily use of gooseberries is safe and can show more significant increase in counts of RBC, Hb in longer duration.
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