No significant structural abnormality of the melanocytes was observed, but rather a functional defect in the transfer of melanosomes from the melanocytes to the keratinocytes.
Adverse reactions associated with ihe use of cosmetics include comedones and folliculitis that substantiate Ihe poieniial (if cosmetic products to induce, aggravate or prolong acne.Acne cosiiiclicu is a parlictiiar lacial variitnl of acne. Il commonly affects young adull women who use cosmetics. Key to the management of acne cosmetica is the avoidance of comedogenic cosmetics. Thus, it is of crucial impotiance to evaluate cosmetics with respect to their comedogenicity. Methods of assessment include animal models, human models and clinical trials. Among thetii. the rabbit ear assay, although not ideal, is the best available.Today, most commercial products are safe. However, dermatologists should remain vigilant and provide the guidelines for beneficial use of cosniclics to acne-prone individtials.
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