SummaryThe purpose of this study was to determine the effect-site concentration of remifentanil that would provide optimal conditions for successful laryngeal mask airway insertion during a target-controlled infusion (TCI) of propofol at 3.5 lg.ml )1 without the use of neuromuscular blockade. Five minutes after propofol infusion, remifentanil was infused at a dose determined by a modified Dixon's up-and-down method. Five minutes after remifentanil infusion, the laryngeal mask was inserted.The effect-site concentration of remifentanil for successful laryngeal mask insertion in 50% of adults (EC 50 ) was 3.04 (SD 0.49) ng.ml )1 during a TCI of 3.5 lg.ml )1 propofol without neuromuscular blockade. From the probit analysis, the EC 50 and EC 95 of remifentanil were 2.84 ng.ml )1 (95% CI 2.09-3.57 ng.ml) and 3.79 ng.ml )1 (95% CI 3.26-9.25 ng.ml )1 ), respectively.
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