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Liposome‐trapped penicillin causes growth inhibition of penicillin‐resistant Staphylococcus aureus (meta 18), Bacillus licheniformis (749/C) and Escherichia coli. Liposome has been prepared from the positively charged, negatively charged and polar lipids of respective organisms. Positively charged liposome containing penicillin causes 77% growth inhibition in the case of Staph. aureus (meta 18) and 61% in the case of Esch. coli. In the case of B. licheniformis (749/C), 40–43% growth inhibition has been observed with liposome‐entrapped penicillin. Homology, composition and charge of liposomes do not seem to have significant effect in percentage inhibition of this organism.

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