Illness intrusiveness -illness-induced life style disruptions -was hypothesized to compromise psychosocial well-being in multiple sclerosis (MS) by (a) interfering with continued involvements in valued activities and interests and (b)decreasing personal control over important life domains. Three categories of illnessrelated variables were hypothesized to contribute to increased illness intrusiveness: burden of illness (i.e., direct physical action and effects of disease), functional deficits (i.e., operational deficits in discrete functional systems), andphysical disabilities (i.e., limitations to the integrated performance of more complex functions). Measures of illness intrusiveness, personal control, psychosocial well-being and illness-related variables were obtained from 94 people with MS on three occasions over 18 months. Surprisingly, all disease and psychosocial variables were highly stable. Hierarchical multiple regression analyses, controlling for recent stressful life events, supported the proposed model. Regression analyses also indicated that each of the hypothesized determinants was significantly and uniquely related to the perception of illness intrusiveness. Approximately two-thirds of participants appeared to achieve a positive psychosocial adjustment to MS. However, the remaining one-third reported elevated levels of emotional distress.
STABILITY AND DETERMINANTS OF PSYCHOSOCIAL WELL-BEING IN MULTIPLE SCLEROSISChronic disabling conditions disrupt the life styles of affected individuals and their families, interfering with continued involvements in valued activities and interests,
Trimethyl tin chloride (TMTC) is a highly toxic organotin compound that affects four main target organs: the brain, liver, immune system and skin. Exposure can occur by inhalation, ingestion or direct skin absorption. Trimethyl tin is but one of many hazardous substances with potentially serious health consequences to which individuals working in research laboratories may be exposed. We report a preventable case of TMTC exposure. Better understanding of the Canadian Workplace Hazardous Materials Information System (WHMIS) legislation and its applicability to the research laboratory situation would prevent such unnecessary exposure to hazardous substances.
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