Uncomplicated AD can be safely treated with the Gore TAG device. Remodelling with thrombosis of the false lumen and reduction of its diameter is induced by the stent graft, but long term results are needed.
The concept of TASP after bEVAR for TAAA is feasible and seems to reduce the risk of SCI. Early side TASP branch completion within 4 weeks is recommended to reduce the risk of rupture, although, according to the individual clinical presentation, a longer TASP interval might improve neurological rehabilitation from SCI.
SUMMARYThe lymphotoxin-b receptor (LT b R) pathway is critical for maintenance of organized lymphoid structures and is involved in the development of colitis. To investigate the mechanisms by which LT b R activation contributes to the pathology of chronic inflammation we used a soluble LT b R-Ig fusion protein as a competitive inhibitor of LT b R activation in the mouse model of chronic colitis induced by oral administration of dextran sulphate sodium. Strong expression of LT b which constitutes part of the LT a 1 b 2 ligand complex was detected in colonic tissue of mice with chronic colitis. Treatment with LT b RIg significantly attenuated the development and histological manifestations of the chronic inflammation and reduced the production of inflammatory cytokines such as TNF, IL-1 b , and IL-6. Moreover, LT b RIg treatment significantly down-regulated mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression, leading to reduced leucocyte rolling and sticking in postcapillary and collecting venules and reduced extravasation into the intestinal mucosa as quantified by in vivo fluorescence microscopy. Thus, LT b R pathway inhibition ameliorates DSS-induced experimental chronic colitis in mice by MAdCAM-1 down-regulation entailing reduced lymphocyte margination and extravasation into the inflamed mucosa. Therefore, a combined treatment with reagents blocking T cell-mediated perpetuation of chronic inflammation such as LT b R-Ig together with direct anti-inflammatory reagents such as TNF inhibitors could constitute a promising treatment strategy for chronic colitis.Keywords DSS-induced colitis LIGHT LT a 1 b 2 LT b R MAdCAM-1
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