We report a case of skin necrosis occurring during coumarin treatment in a patient with acquired protein S deficiency and the primary antiphospholipid antibody syndrome.
Our study indicates an increased prevalence of autoantibodies in SAPHO syndrome, with no specific profile. We failed to confirm the reports of an increased prevalence of antithyroid antibodies. These results tend to support a link between autoimmunity and SAPHO syndrome.
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