A micellar electrokinetic chromatograpliic method which permits the separation of very similar compounds such as ethinylestradiol (ETE), gestodene (GTD), (-)norgestrel (LEV) and p-estradiol valerate (EST) from synthetic mixtures is described. The study was carried out at 25°C and 20 kV, using a 15 mM borate •Tel. 2454 BERZAS, CASTANEDA, AND PINILLA buffer (pH 9.2), 15 mM sodium dodecylsulfate (SDS) and 26 % acetonitrile-water as background electrolyte. The analysis takes about 12 minutes.

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SummaryA micellar electrokinetic chromatographic method is presented which permits quantification of ethinylestradiol and gestodene in pharmaceutical products. Separation was carried out at 25~ and 25 KV, using a 20 mM borate buffer (pH 9.2), 15 mM sodium dodecylsulfate in 30% acetonitrile-water (v/v). Under these conditions analyses were carried out in 7 min. Four different oral contraceptives were analysed and the results compared favourably with those of a reference liquid chromatographic method.

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