Purpose: The aim of this study was to evaluate the effect of epinephrine (Epi) or felypressin (Fely) contained in dental local anesthetics on myocardial oxygen balance.Methods: Male Japan White tracheotomized rabbits were anesthetized with isoflurane. Three doses of 0.18, 0.36, and 0.72 ml of 2% lidocaine hydrochloride containing 1: 80,000 Epi or 3% prilocaine hydrochloride containing 0.03 IU/ml Fely were injected into the rabbit tongue muscle. These doses were equivalent to 2, 4, and 8 of dental local anesthetic cartridges in humans weighing 50 kg by body weight correction, respectively. Heart rate (HR), blood pressure, aortic blood flow (AoF), According to the reviewers' thoughtful and suggestive comments, we revised the manuscript. The revised parts are listed in the following paper.We hope you will appreciate the significance of our intention, and look forward to your favorable decision. Dear the editor-in-chief and reviewers Thank you very much for kindly reviewing our manuscript and giving us valuable comments and suggestions. We have made revisions based on these comments and suggestions. Please find point-to-point descriptions of how we responded to the reviewer's comments, suggestions, and criticisms. We hope the revision meets the demand by the editor and reviewers, and that our revised manuscript will be acceptable for publication in
Objective: To verify the validity of the prediction of oral intake recovery for inpatients with aspiration pneumonia using the Hyodo-Komagane score. Background: Patients admitted for treatment of aspiration pneumonia sometimes have difficulty in resuming oral intake due to decreased swallowing function. Predicting whether the swallowing function will recover enough to achieve oral ingestion at discharge is an important factor in developing a treatment strategy. No studies have investigated the prediction of oral intake recovery using videoendoscopic examination. Methods: Subjects were 65 patients who were admitted to an acute care hospital for the treatment of aspiration pneumonia. The patients were divided into two groups, the oral feeding group and the tube feeding group, according to their oral intake status at discharge or transfer. Logistic regression analysis was performed using the condition that tube feeding was not required as an objective variable and the items with significant differences between the two groups as explanatory variables. Additionally, the receiver operating characteristic curve was used to identify patients who could take food orally at discharge. Results: The odds ratios for the Hyodo-Komagane score and the pharyngeal clearance score were 1.485 and 3.379, respectively. When the cutoff values of the Hyodo-Komagane score and the pharyngeal clearance score were 6 and 1, the sensitivity was 0.88 and 0.91, and the specificity was 0.64 and 0.70, respectively. Conclusion: The Hyodo-Komagane score and especially the pharyngeal clearance score are useful indices to predict oral intake recovery for inpatients with aspiration pneumonia. K E Y W O R D S aspiration pneumonia, dysphagia, oral intake, oral rehabilitation, predict, videoendoscopic How to cite this article: Kimura M, Nakayama E, Ogawa Y, et al. Prediction of oral intake recovery for inpatients with aspiration pneumonia by videoendoscopic evaluation using the Hyodo-Komagane score in Japan.
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