Several clinical studies have shown a large number of mental symptoms by immunomodulatory treatment with interferon (IFN). The most frequently described symptoms are depression, suicidal behaviour, manic symptoms, anxiety, psychosis and delirium, associated with other non-specific symptoms such as fatigue, irritability, psychomotor retardation, decreased libido, insomnia, difficulty in concentration and attention. Having a history of mental disorder contraindicates the use of IFN-alpha. These adverse effects that affect the mental state appear usually at the beginning of the treatment (most after 3 weeks of treatment). The incidence of psychotic episodes is low and the episodes usually remit when treatment is interrupted; only some cases require antipsychotic treatment. We present the case of a patient affected with hepatitis C who began to present self-referential delirious symptoms after receiving the treatment with IFN and who was successfully treated with paliperidone. This patient could be classified within the group of high-risk psychiatric patients given the family history of schizophrenia and his personal history of illegal drug consumption. The pharmacological actions of paliperidone are similar to other high potency atypical antipsychotics. The receptor-binding profile of paliperidone most closely resembles that of risperidone and ziprasidone. Paliperidone differs from risperidone and most other antipsychotics by its relatively low extent of enzymatic hepatic metabolism. To the best of our knowledge, this is the first case described that was successfully treated with paliperidone.
IntroductionThe two-pole disorder is one of the diagnoses more prevalent to the hospitable revenue of the patients in the UHSM-HUSC. Nowadays there is scanty the knowledge of the pat physiology of this disease. Therefore, in the last years an advance has taken place in the different pharmacological therapies used for this disorder, being variable the current available evidence.AimsTo analyze the prescription to the hospitable discharge of lithium, anti-epileptic, antipsychotic atypical medicaments and antipsychotic typical in patients.MethodsWe realize a descriptive retrospective study of the prescribed treatments. The different alternatives of treatment analyzed are: antipsychotic atypical medicament, antipsychotic typical medicament, lithium and anti-epileptic in monotherapy or mixed. We use as sample all the patients’ income that have the criteria of two-pole Disorder, current maniacal episode con/without psychotic symptoms according to the CIE-10 that have taken place in the triennium in the UHSM-HUSC of Granada. The obtained information was submitted to statistical analysis(SPSS v.16.0)ResultsThe medicaments prescribed with more frequency are the lithium in monotherapy or partner to antipsychotic atypical being the trend the use of the acid valproico in monotherapy or from concomitant form to antipsychotic atypical. The medicaments fewer employees are the acid valproico and the antipsychotic atypical ones in monotherapy.ConclusionsIt was prescribed as treatment to the hospitable discharge in patients during the triennium principally lithium or acid valproico partners to antipsychotic atypical being the trend the use of acid valproico associated to antipsychotic atypical. The use of antipsychotic typical was more limited.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.