Breast cancer is one of the most important problems of modern oncology. Intracystic cancer in the structure of malignant breast neoplasms belongs to one of the most rare forms and is a variant of intraductal papillary cancer. The issues of early diagnosis of this pathology remain controversial today. The aim of this work was to improve the algorithm of differential diagnosis of intracystic breast cancer and cystic mastopathy. Within the framework of this study, we examined 153 female patients of the prospective group with suspected breast cyst cancer and analyzed the results of examinations carried out for 59 patients of the retrospective group who were examined and treated for intracystic breast cancer in the period from 2010 to 2015 on the basis of Smolensk Regional Oncological Clinical Dispensary. The standard algorithm for examining the patients with suspected intracystic breast cancer in the framework of this study included multiparametric ultrasound (ultrasound in B-mode, ultrasonic Doppler examination, strain elastography, shear wave elastography) and fine needle aspiration puncture biopsy according to our improved technique with subsequent evaluation of the new algorithm's effectiveness. We drew conclusions on low sensitivity and specificity of the traditional algorithm for examining patients with suspected intracystic breast cancer, about a greater effectiveness of the improved algorithm for this diagnosis and advisability to use fine needle aspiration puncture biopsy using the ozone-oxygen mixture to improve the diagnosis of intracystic cancer at the preoperative stage.
The article presents the results of the use of a new improved method of cytologic diagnostics of cancer in a breast cyst by applying hybrid technologies. By using our new created method with the application of ozone-oxygen mixture, unlike the traditional method of fine needle aspiration biopsy of breast cysts with a solid parietal component, the probability of obtaining unaltered atypical cells in the punctate in the presence of malignization increases, thereby promoting the informativeness and sensitivity of this diagnostic method.
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