Conclusion: Modification of standard ROTEM channels using un-activated testing with heparinase addition demonstrates the expected reduced clotting times and increased clot firmness in COVID-19 associated hypercoagulability. Use of therapeutic and prophylactic anticoagulation was common in this population, and results of heparinase to ROTEM testing eliminates this confounding effect. Longitudinal assessment shows normalization of multiple hypercoagulable effects in COVID-19 disease around days 9-11 in this moderately ill cohort.
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