The AFFIRM Study enrolled 4060 predominantly elderly patients with atrial fibrillation to compare ventricular rate control with rhythm control. The patients in the AFFIRM Study were representative of patients at high risk for complications from atrial fibrillation, which indicates that the results of this large clinical trial will be relevant to patient care.

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The prevalence of sensitization to formaldehyde releasers (FRs) differs according to geographic area and has changed over time. Several factors may influence prevalence, including different patch test systems or concentrations or the allergen selection in different baseline patch test series, habits of the populations, and regulations and legal concentration limits in cosmetics. 1,2 Quaterium-15 had been SANZ-SÁNCHEZ ET AL. 173

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