The infrared radiation caused by the heat of reaction of an enantioselective enzyme-catalyzed transformation can be detected by modern photovoltaic infrared (IR)-thermographic cameras equipped with focal-plane array detectors. Specifically, in the lipase-catalyzed enantioselective acylation of racemic 1-phenylethanol, the (R)- and (S)-substrates are allowed to react separately in the wells of microtiter plates, the (R)-alcohol showing hot spots in the IR-thermographic images. Thus, highly enantioselective enzymes can be identified at kinetic resolution.
Regioselective Palladium-Catalyzed Coupling Reactions of Vinyl Chlorides with Carbon Nucleophiles.-The title reaction involves vinyl-allyl isomerization via CH-activation followed by nucleophilic attack of Cnucleophiles on the intermediate palladium-π-allyl species. Only vinyl chlorides bearing methyl groups in the 2-position undergo this reaction. -(REETZ, M. T.; WANNINGER, K.; HERMES, M.; Chem. Commun. (Cambridge) (1997) 6, 535-536; MPI Kohlenforsch., D-45470 Muelheim/Ruhr, Germany; EN)
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