Summary. Traumatism around the world is taking on unmanageable proportions. Suffice it to say that every year on a global scale, several million people die from traffic accidents and industrial and domestic injuries. Some die from the actual damage, and most die from purulent-inflammatory complications. The urgency of the problem. Treatment of inflammatory complications requires significant funds for antibacterial drugs, but their more considerable amount is insufficient given the resistance of the microflora. Aim. To substantiate the expediency of antibacterial therapy and methods of its application. Materials and methods. Several experimental studies were conducted on rabbits to reveal the inhibitory effect of antibacterial drugs that enter the internal organs with various administration methods. Results and their discussion. It turned out that after intramuscular administration, ceftriaxone accumulates in the organs of the abdominal cavity in an insufficient amount to inhibit the growth of microflora. After intravenous administration, ceftriaxone gets in the appendix in 60 % of the control after 1 hour, and after 2 hours, it decreases to 30 %, which is not very effective. After lymphotropic administration, the antibiotic accumulates after 1 hour in an amount sufficient for antibacterial action (70 %) and after 2 hours — in 95 %, which is evidence of the targeting and accumulation of antibiotics with such administration of the drug. Conclusions. Taking into account the significant disruption of microcirculation in the impression zone, the «mileage» of the vascular bed, the aggregation of formed blood elements in microvessels, and the formation of microthrombi, the intravenous method of drug administration in traumatic disease cannot be considered optimal. This need is met by the lymphotropic way of delivering antibiotics to various organs of the abdominal and thoracic cavities.
Summary. The aim of the work was to study the possibility and effectiveness of antibiotic therapy for appendicular infiltrate using the proposed lymphotropic technology. The results of treatment of patients with appendicular infiltrate of the two studied groups were analyzed. In the main group (47 patients), lymphotropic administration of antibacterial drugs was performed. The comparison group (47 people) received standard antibiotic therapy. At the same time, it was possible to reduce the period of inpatient treatment from 12-14 days to 6-7. In the late period, during surgical treatment of patients of the main group, no adhesions were found in the abdominal cavity, and in patients of the comparison group, such changes were found in 74 % of the operated patients, which indicates a positive effect of lymphotropic antibiotic therapy. The proposed method of antibiotic therapy improves the results of treatment, saves financial costs for treatment and ensures the timely return of the operated person to socially useful work.
Summary. Aim. The purpose of the work was to study the possibility of alternative antibacterial therapy by the type of lymphotropic targeted accumulative antibiotic therapy for injuries of the abdominal cavity. Materials and methods. To implement it, we studied in an experiment the accumulation of the antibiotic in the tissues of various organs of rabbits after its lymphotropic administration. Results of the research. The experiment proved, that lymphotropic antibiotic therapy, depending on the place of regional administration of the drug, contributes to the targeted accumulation of the antibiotic in the corresponding organ in an amount sufficient for a persistent antibacterial effect. Conclusions. The proposed method of administration of antibacterial drugs may be the most appropriate for injuries of the abdominal cavity and retroperitoneal space, as it significantly reduces the likelihood of purulent-septic complications and makes it possible to significantly reduce the length of stay of patients in the hospital, reduce the amount of financial costs and early return to socially useful work.
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