Converting Enzyme (ICE) Inhibitor.-The title compound PD 194035 (XIII), a previously described peptidomimetic ICE inhibitor, is prepared in an stereoselective fashion using Evan's chiral auxiliary (I). This modified 18-step synthesis is more efficient and provides better overall yield (9.8%) than published procedures. -(CHEN, M. H.; GOEL, O. P.; HYUN, J.-W.; MAGANO, J.; RUBIN, J. R.; Bioorg. Med. Chem. Lett. 9 (1999) 11, 1587-1592; Parke-Davis Pharm. Res. Div., Warner-Lambert Co., Ann Arbor, MI 48105, USA; EN)
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