The combination of 3 mg drospirenone/30 microg ethinylestradiol (Yasmin, Schering AG) reliably inhibits ovulation, with a low frequency of follicular maturation, and provides a reasonable safety margin.
A bteilun g Fra ue nheilkunde im Ze ntrum Op erative Medi zin l de r Chrisnan-Albr echts-Unive rsität und Michachs-Hcburnmcnschulc zu Kiel (Direkto r: ". Pr"f. Dr. med. Dr. mcd. vct. h. c. K. Semm) Ze ntr um Fraue nhe ilkunde und Ge burtshilfe de s Klinikums de r Johann-Wnlfgang-Gnelhe-U ni\'crsitiitLU Fra nkfurt 'Im Main [ Direktor: o. Pro f. Dr. med. 11. Schm idl-Ma llhi C'i<;n l Klinik um der Jt>hann• Wolfg;lIlg-(j oclh c-Uni \"ersit;il lU Frankfurt a m Mam (Di rekt" r; o. Prof. Dr. rned. V. \'o n t. ocwc nich j c c c 1400 ß o c c 1200-g o c 1 000-g :-' 00 c c c 8OO' 0 "1lll c o c. .-0
This is a retrospective study which evaluates the use of twice-daily (BID) human menopausal gonadotropin (hMG) for follicular stimulation in an in vitro fertilization and embryo transfer (IVF-ET) program from February to June 1985 and compares it to daily (QD) hMG from August to December 1984. All QD patients were begun on 2 ampoules of hMG, and BID patients on 2 ampoules twice daily. Individual patient responses to hMG determined subsequent doses so as to achieve continuously rising estradiol levels. The BID stimulation scheme appears to increase statistically characteristics that would be present in the ideal stimulated cycle such as elevated follicular-phase estradiol (E2) (2125 pg/ml for the BID vs 1581 pg/ml for the QD group) with an increase in the number of patients achieving the "desired" Jones pattern, increased oocyte retrieval (4.01 vs 2.45), and an increase in the number of transferred concepti (2.69 vs 1.87). No statistical differences were noted in the number of endogenous luteinizing hormone (LH) surges or mean LH. The luteal phase does not appear to have been altered by the frequency of administration. Although the increase in the total (20.0 vs 14.5%) and live-born/ongoing (16.9 vs 11.8%) pregnancy rate per laparoscopy with the BID regimen is not statistically significant, it may be that it is clinically relevant.
A case is reported of sonographic diagnosis of ADAM-complex (amniotic band syndrome) in the 19th week of gestation of an otherwise healthy pregnancy. The ultrasonic investigation showed absence of bony structures in the skull area a direct connection to the placenta. The intra-cerebral structures showed no abnormalities. Aminocentesis demonstrated normal chromosomal analysis and an alpha-fetoprotein value was within normal limits. The acetylcholinesterase examination was negative. Following prostaglandin induction, a spontaneous delivery of a 230 g freshly dead fetus occurred, the latter exhibiting a broadly-based amniotic band connection between skull and placenta.
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