The aims of this study were to examine the efficacy of the Incredible Years program (IY) with Portuguese families of preschoolers, moderator and mediator effects, and sustainability of results. Design: randomized controlled design with pre-and postintervention, 12 and 18 months assessments. Participants: 124 children aged 3-6 years, at risk of disruptive behavior problems. Children in the IY group showed significant reduction in behavior problems and increase in social skills; caregivers improved parenting practices and self-confidence. Positive clinical and functional impacts were demonstrated. IY was efficacious with a wide range of families. The moderating effect of the child's age suggests that IY prevents a decrease in social skills for the ages covered by this study. Changes in parental self-efficacy affected changes in parental practices, promoting changes in children's behavior. Positive effects were maintained over time.

The hippocampus is a brain region involved in processing both memory and emotions, through a preferential involvement of the dorsal hippocampus (DH) and ventral hippocampus (VH), respectively. Adenosine A1 and A2A receptors (A1R and A2AR) control both mood and memory, but it is not known if there is a different adenosine modulation of synaptic plasticity along the hippocampal axis. Using adult, C57BL/6 male mice, we show that both A1R and A2AR were more abundant in DH compared with VH. However, recordings of field excitatory postsynaptic potentials at Schaffer collaterals‐CA1 pyramidal synapses revealed that A1R were equi‐effective to inhibit basal excitatory synaptic transmission in DH and VH, but endogenous A1R activation was more effective to depress the probability of release in VH. In contrast, the selective A2AR antagonist (SCH58261, 50 nM) controlled both long‐term potentiation (induced by a high frequency stimulation protocol) and long‐term depression (induced by a low frequency stimulation protocol) selectively in DH rather than VH, whereas the selective A1R antagonist (DPCPX, 100 nM) revealed a similar tonic inhibition of long‐term depression in DH and VH. These findings show a different control of synaptic plasticity by the adenosine modulation system in the dorsal and ventral poles of the hippocampus, which may underlie a different efficiency of the adenosine system to control mood and memory.

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Objective To compare structured clinical assessment versus research measurement of suicidal risk among inpatients with major depression. Methods 50 depressed inpatients underwent a structured clinical and an independent research assessment of suicidal risk. Agreement between both assessments and its impact upon time to first readmission was tested. Results A false negative rate of 25% in the clinical screening of past suicide attempts was associated with older age, concealment and reported lower frequency of suicidal thoughts. Mean times to first readmission (2.5-years follow-up) were 74 weeks (discordant responders) and 118 weeks (concordant responders). Conclusion A failure to detect 25% of patients with past suicide attempt history in the clinical assessment was associated with older age and concealment of suicidal thoughts.